Thermal dose and thermal isoeffect dose

Thermal dose and radiation dose comparison based on cell survival

Background/introduction The biologic dose response curves of thermal dose and absorbed radiation dose have not been compared to each other even though they have both been extensively investigated separately and combined. Although heat and radiation produce cell kill by different biological mechanisms (Thermal dose denatures proteins and the radiation dose causes DNA damage) a comparison of dose...

No universally applicable thermal dose descriptor.

A new isoeffect curve for change in dose per fraction.

A method is proposed for using survival curve parameters for calculating the change in total dose necessary to achieve an equal response in a tissue when the dose per fraction is varied. The method uses the ratio alpha/beta of the coefficients of the linear quadratic survival formula and accounts only for the effect of repair of cellular injury. Absolute values for alpha and beta are not requir...

Fractionated irradiation of carbon beam and the isoeffect dose on acute reaction of skin

Materials and methods: Mice: C3H/HeMsNrsf female mice aged 4 months old were used for this study. The animals were produced and maintained in specific pathogen-free (SPF) facilities. Irradiation: The mice right hind legs received daily fractionated irradiation ranged from single to six fractions. Carbon ions (C) were accelerated by the HIMAC synchrotron to 290 MeV/u. Irradiation was conducted u...

Measuring the photon and thermal neutron dose values of contralateral breast surface undergone breast cancer radiation therapy

This research aimed to measure the received photon and thermal neutron doses to contralateral breast (CB) surface in breast cancer radiation therapy for different field sizes in presence of dynamic and physical wedges. The photon and thermal neutron doses were measured by thermo uminescent dosimeter (TLDs) chips for 11 × 13, 11 × 17 and 11 × 21 cm2 field sizes in presence of physical and dynamic ...